Qualitative and Quantitative Changes in Coronary Plaque Associated With Atorvastatin Therapy
نویسندگان
چکیده
منابع مشابه
Qualitative and quantitative changes in coronary plaque associated with atorvastatin therapy.
BACKGROUND The aim of this study was to elucidate the time course of atorvastatin-induced changes in vulnerable plaque using angioscopy and intravascular ultrasound (IVUS). METHODS AND RESULTS Fifty-seven hypercholesterolemic patients with coronary artery disease (CAD) were treated with atorvastatin (10-20 mg/day) for 80 weeks and then coronary plaques were evaluated with angioscopy and IVUS....
متن کاملChanges in coronary plaque color and morphology by lipid-lowering therapy with atorvastatin: serial evaluation by coronary angioscopy.
OBJECTIVES Changes in coronary plaque color and morphology by statin therapy were evaluated using coronary angioscopy. BACKGROUND Coronary plaque stabilization by statin therapy has not been clarified in humans. METHODS Thirty-one patients with coronary artery disease were divided into either the comparison group (n = 16) or the atorvastatin group (n = 15). Before treatment and 12 months af...
متن کاملPlasma oxysterol level in patients with coronary artery stenosis and its changes in response to the treatment with atorvastatin
Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol. Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during...
متن کاملCoronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin
BACKGROUND Nonobstructive coronary plaques manifesting high-risk morphology (HRM) associate with an increased risk of adverse clinical cardiovascular events. We sought to test the hypothesis that statins have a greater anti-inflammatory effect within coronary plaques containing HRM. METHODS AND RESULTS In this prospective multicenter study, 55 subjects with or at high risk for atherosclerosis...
متن کاملCoronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin
It is well accepted that the presence of nonobstructive atherosclerotic plaques, particularly those with high-risk morphological (HRM) features, is associated with an increased risk of future cardiovascular disease events. This observation has led to proposals to use data on nonobstructive plaque characteristics (if available) to alter the thresholds for prescribing lipid-lowering drugs for pri...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2009
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-08-0755